Oxfordians everywhere, including yours truly, celebrate a triumphant win in court:
...the judge observed that labor laws, when ambiguous, are designed to benefit the laborers, the case was settled.
"For want of a comma, we have this case," the judge wrote.
Ambiguity is the enemy of clear communication, and the Oxford comma reduces ambiguity. It's as simple as that. If you want to be a sophist, then that's fine, but do it in academia or politics or something. Don't do it in labor contracts, and don't do it in genre fiction.